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IN-Perium Frequently Asked Questions

Can I use IN-Perium while fasting?

There are several schools of thought on fasting. A popular rule of thumb is that one can consume up to 50 calories during a fasting period without breaking the fast. If you subscribe to this principle, a serving of IN-Perium is nowhere close to ending your fast.

Some people, including Dr. Jaquish, would also maintain that the benefits of fasting are derived from the absence of an insulin response. If you are participating in an insulin restriction fast, you may be pleased to know that a majority of the 25 calories in IN-Perium are from fat, which causes no insulin response. The concept of ‘insulin fasting’ is the basis for substituting coffee with butter and MCT oil for an ordinary breakfast, and you can make the same substitution with IN-Perium.

Furthermore, if one is fasting in an effort to promote autophagy, it is worth noting that ingredients in IN-Perium may well accelerate the onset of that process. Studies have shown that caffeine itself and decaffeinated coffee both promote autophagy in mice [1][2], and observational evidence discussed in that research suggests this effect may occur in humans as well.

IN-Perium contains both caffeine and coffee extract. Likewise, research suggests that ketone bodies may promote autophagy [3], and the body can easily convert the MCT oil in IN-Perium to ketone bodies following consumption.

When’s the best time to take IN-Perium?

We recommend taking IN-Perium either before your workout or at the time that you would otherwise consume coffee.

What does IN-Perium taste like?

IN-Perium has a lemon citrus flavor.

What are the ingredients in IN-perium?

Caffeine: Caffeine has been shown to improve physical performance, including muscular and cardiovascular endurance, and performance in high intensity anaerobic exercise. This is in addition to improved mental performance, such as improved reaction times, concentration, and wakefulness.

Medium Chain Triglycerides: These are easily converted to ketones and provide readily available energy for the body. This can also help IN-Perium to act as an appetite suppressant for those practicing insulin restriction fasting.

Beta-Alanine: This isomer of the amino acid Alanine has been shown to increase muscular performance, especially during periods of intense exertion from 1 to 5 minutes, perfect for getting that extra couple reps in your X3 set! Performance improvements have been shown for recreational, competitive, and tactical athletic endeavors, and some research suggests a cognitive enhancement effect as well.

Electrolytes: IN-Perium contains Na, K, and Mg. Sodium (Na) and Potassium (K) are essential electrolytes that are critical for cellular function, blood pressure regulation, and muscle and nerve activation. Magnesium is a necessary electrolyte associated with positive impacts on blood glucose, HbA1c, and insulin sensitivity. Deficiency can lead to high blood pressure. Magnesium is primarily naturally occurring in nuts and leafy green vegetables, so deficiency can easily occur with typical western diets.

L-Theanine: This amino acid is not commonly found in food, but is naturally occurring in green tea. Especially when combined with caffeine, L-Theanine has been shown to improve cognition and attention, and has been reported to help mitigate the “jittery” feelings that some individuals associate with caffeine consumption. It also may contribute to the positive health effects associated with green tea consumption in other research.

L-Citrulline: There is evidence L-Citrulline reduces fatigue during exercise and improves exercise performance[4], aids recovery, increases arginine and creatine levels, and boosts GH production[5].

Coffee Extract: Because IN-Perium is suitable for use as a coffee replacement, it contains an extract of natural coffee to provide the other likely beneficial compounds found in coffee, since there is robust evidence that coffee consumption has health benefits beyond those attributable exclusively to the caffeine it contains.

How does IN-Perium compare to other MCT oil products?

In addition to all of the other ingredients and benefits IN-Perium offers beyond the MCT component, IN-Perium is also an easily-dissolvable powder, and yet it does not contain maltodextrin, giving it yet another advantage over many other MCT products which either require a blender or contain maltodextrin.

How is IN-Perium different than other pre-workout products?

IN-Perium is different from other potentially competitive products because it contains MCT oil and electrolytes, two ingredients that are going to be of particular interest to the often-fasting, often-low-carb followers of X3. Because of this, IN-Perium can replace pre-workout/coffee AND replace an electrolyte product AND replace MCT oil products.

IN-Perium is additionally superior to ordinary pre-workouts because it does not contain any artificial sweeteners and it contains a superior portfolio of ingredients.

There are 9 active ingredients: Caffeine, Medium Chain Triglycerides, Beta-Alanine, Sodium, Potassium, Magnesium, L-Theanine, L-Citrulline, and Coffee Berry Extract.

Does IN-Perium need to be refrigerated?

No, IN-Perium does not need to be refrigerated. We recommend storing in a cool, dry place.

Why didn’t you include these ingredients in IN-Perium?

Taurine: This is a popular supplement ingredient, however the best evidence we could find supporting any beneficial effect from Taurine came from one really tiny, poorly designed study. The aforementioned study [7] showed increased maximal effort athletic performance and reduced oxidative damage to muscle cell DNA, but the study was pre-to-post without a placebo group and had n of 11. Other research shows that Taurine improves blood flow in diabetics and increases insulin sensitivity in mice [8]. It also improves cardiovascular function and prevents oxidative damage in iron overloaded mice [9]. Taurine supplementation appears to depress platelet aggregation in humans [10]. Basically, the evidence seems to suggest that Taurine supplementation could offer health benefits in some circumstance, but we don’t see any robust evidence that suggests it would provide significant benefit to healthy humans, and we don’t want to include any ingredients without good reason.

Arginine: Citrulline can be converted to Arginine as needed, rendering Arginine redundant. Also, there is far less research supporting any outcome based efficacy of arginine as a supplement than there is for Citrulline. There is no reason to include this since we already include Citrulline.

Vitamin B12: There’s research noting a correlation between B12 supplementation and increased cancer risk in men[11]. This is ‘survey science’, but the hazards ratio 95% CI is 1.32 to 2.97, which potentially indicates serious correlation, and that makes us think we should exercise the precautionary principle here and exclude this ingredient, especially since IN-Perium is not intended to be a vitamin drink.

Theacrine: This compound is related to caffeine, and popular in some supplements, but we could not find efficacy for any particular unique benefits. Compared to caffeine, greater dosages of Theacrine are required to obtain a stimulatory effect, and at lesser dosages it acts as a sedative[12]. The volume of research on Theacrine is also much lower than for caffeine, so inclusion seemed unwise.

Orthinine: This chemical is converted into L-Citrulline and the body of research on Orthinine seems to show inferior efficacy to L-Citrulline supplementation. For example, in one study [13] that demonstrated a diminishment of reported fatigue with orthinine supplementation, the male cohort failed to demonstrate improved athletic performance versus placebo, whereas in a similar study on L-Citrulline [14], a larger cohort of male subjects did demonstrate significantly improved athletic performance versus placebo. Furthermore, the performance improvement in the Citrulline study [15] was more relevant to our application given that the exercise in question was weight training, as compared to the cycling ergometer testing in the study on Orthinine. Since IN-Perium already provides L-CItrulline, Orthinine appears somewhere between redundant and pointless.

Tyrosine: This appears to improve cognition during periods of prolonged sleep deprivation [16] and for people exposed to extremely cold temperatures [17]. Tyrosine combined with a protein shake has been shown to improve cognitive performance when compared to a placebo beverage containing 255 calories of sugar water, in a study [18] apparently designed to ensure that no one learned anything useful about the effects of Tyrosine in isolation. Tyrosine has been shown to improve cycling performance in warm conditions [19] and also to fail to improve cycling performance in warm conditions [20] at the same exact dosage. There is no reliable evidence that Tyrosine would provide a benefit useful to the X3 audience, so it is not included.